{"id":40194,"date":"2026-02-21T16:30:05","date_gmt":"2026-02-21T16:30:05","guid":{"rendered":"https:\/\/bihavadis.com\/?p=40194"},"modified":"2026-02-21T16:30:05","modified_gmt":"2026-02-21T16:30:05","slug":"sessiz-ilerleyen-genetik-hastaliga-karsi-erken-tani-ve-dogru-yonetim-hayat-kurtariyor","status":"publish","type":"post","link":"https:\/\/bihavadis.com\/index.php\/2026\/02\/21\/sessiz-ilerleyen-genetik-hastaliga-karsi-erken-tani-ve-dogru-yonetim-hayat-kurtariyor\/","title":{"rendered":"Sessiz \u0130lerleyen Genetik Hastal\u0131\u011fa Kar\u015f\u0131 Erken Tan\u0131 ve Do\u011fru Y\u00f6netim Hayat Kurtar\u0131yor"},"content":{"rendered":"<p><strong>Necmettin Erbakan \u00dcniversitesi T\u0131p Fak\u00fcltesi, \u0130\u00e7 Hastal\u0131klar\u0131 Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Nefrolog Prof. Dr. K\u00fcltigin T\u00fcrkmen<\/strong>, Otozomal Dominant Polikistik B\u00f6brek Hastal\u0131\u011f\u0131\u2019n\u0131n (ODPKD) toplumda san\u0131landan daha yayg\u0131n g\u00f6r\u00fclen, ancak fark\u0131ndal\u0131\u011f\u0131 h\u00e2l\u00e2 yeterli olmayan ciddi bir genetik hastal\u0131k oldu\u011funa dikkat \u00e7ekiyor.<\/p>\n<p>\u201c<strong>ODPKD, b\u00f6breklerde \u00e7ok say\u0131da s\u0131v\u0131 dolu kistin olu\u015fmas\u0131yla seyreden, kal\u0131tsal ve ilerleyici bir hastal\u0131kt\u0131r. D\u00fcnya genelinde her 400\u20131000 do\u011fumdan birinde g\u00f6r\u00fcl\u00fcr ve diyaliz ya da b\u00f6brek nakli gerektiren son d\u00f6nem b\u00f6brek yetmezli\u011finin en \u00f6nemli d\u00f6rt nedeninden biridir<\/strong>\u201d diyen Prof. Dr. T\u00fcrkmen, hastal\u0131\u011f\u0131n erken d\u00f6nemde tan\u0131nmas\u0131n\u0131n kritik \u00f6nem ta\u015f\u0131d\u0131\u011f\u0131n\u0131 vurguluyor.<\/p>\n<p><strong>Genetik Bir Miras<\/strong><\/p>\n<p>Prof. Dr. K\u00fcltigin T\u00fcrkmen, hastal\u0131\u011f\u0131n tamamen genetik ge\u00e7i\u015fli oldu\u011funu belirterek \u015fu bilgileri payla\u015f\u0131yor:<br \/>\u201c<strong>Vakalar\u0131n yakla\u015f\u0131k %85\u2019i PKD1, %15\u2019i ise PKD2 genindeki mutasyonlardan kaynaklan\u0131r. PKD1 mutasyonu olan hastalarda hastal\u0131k daha erken ya\u015fta ve daha a\u011f\u0131r seyrederken, PKD2 mutasyonu olanlarda genellikle daha yava\u015f ilerler<\/strong>.\u201d<\/p>\n<p>T\u00fcrkmen\u2019e g\u00f6re, ki\u015fi bu genetik yatk\u0131nl\u0131kla do\u011fsa da kistlerin olu\u015fumu i\u00e7in ya\u015fam boyunca h\u00fccrelerde ikinci bir tetikleyici mekanizman\u0131n devreye girmesi gerekiyor.<\/p>\n<p><strong>Sadece B\u00f6brekleri De\u011fil, T\u00fcm V\u00fccudu Etkiliyor<\/strong><\/p>\n<p>\u201c<strong>ODPKD yaln\u0131zca bir b\u00f6brek hastal\u0131\u011f\u0131 de\u011fildir; t\u00fcm v\u00fccudu etkileyen sistemik bir hastal\u0131kt\u0131r<\/strong>\u201d diyen Prof. Dr. T\u00fcrkmen, b\u00f6brek yetmezli\u011fi geli\u015fmeden \u00e7ok \u00f6nce hastalar\u0131n \u00f6nemli bir k\u0131sm\u0131nda\u00a0<strong>y\u00fcksek tansiyon<\/strong>\u00a0g\u00f6r\u00fcld\u00fc\u011f\u00fcn\u00fc belirtiyor.<\/p>\n<p>Hastal\u0131\u011f\u0131n b\u00f6breklerle ili\u015fkili en s\u0131k belirtileri aras\u0131nda:<\/p>\n<ul>\n<li>Kronik bel ve yan a\u011fr\u0131s\u0131,<\/li>\n<li>\u0130drarda kanama ve enfeksiyon ataklar\u0131,<\/li>\n<li>B\u00f6brek ta\u015f\u0131 olu\u015fumu bulunuyor.<\/li>\n<\/ul>\n<p>B\u00f6brek d\u0131\u015f\u0131 bulgulara da dikkat \u00e7eken T\u00fcrkmen, \u201c<strong>Karaci\u011fer kistleri en s\u0131k g\u00f6r\u00fclen b\u00f6brek d\u0131\u015f\u0131 bulgudur. Ayr\u0131ca baz\u0131 hastalarda beyin damarlar\u0131nda anevrizma riski ve kalp kapak\u00e7\u0131\u011f\u0131 sorunlar\u0131 g\u00f6r\u00fclebilir. Bu nedenle hastalar \u00e7ok y\u00f6nl\u00fc de\u011ferlendirilmelidir<\/strong>\u201d ifadelerini kullan\u0131yor.<\/p>\n<p><strong>Tan\u0131 Basit, Takip Hayati<\/strong><\/p>\n<p>Prof. Dr. K\u00fcltigin T\u00fcrkmen\u2019e g\u00f6re ODPKD tan\u0131s\u0131 \u00e7o\u011fu zaman ultrason ile konulabiliyor.<br \/>\u201c<strong>Manyetik rezonans (MR) g\u00f6r\u00fcnt\u00fcleme, b\u00f6brek hacmini \u00f6l\u00e7erek hastal\u0131\u011f\u0131n ne kadar h\u0131zl\u0131 ilerleyece\u011fini \u00f6ng\u00f6rmemizi sa\u011flar. Aile \u00f6yk\u00fcs\u00fc olmayan ya da tan\u0131s\u0131 netle\u015fmeyen hastalarda genetik testler \u00f6nemli bir destek sa\u011flar<\/strong>\u201d diyor.<\/p>\n<p><strong>Hastal\u0131\u011f\u0131n Seyri De\u011fi\u015ftirilebiliyor<\/strong><\/p>\n<p>ODPKD\u2019yi tamamen ortadan kald\u0131ran bir tedavi hen\u00fcz bulunmasa da, hastal\u0131\u011f\u0131n ilerlemesini yava\u015flatman\u0131n m\u00fcmk\u00fcn oldu\u011funu vurgulayan Prof. Dr. T\u00fcrkmen, \u015fu noktalara dikkat \u00e7ekiyor:<\/p>\n<p>\u201c<strong>Bol su t\u00fcketimi, tuz k\u0131s\u0131tlamas\u0131 ve tansiyonun s\u0131k\u0131 kontrol\u00fc tedavinin temelini olu\u015fturur. Bunun yan\u0131 s\u0131ra, uygun hastalarda kullan\u0131lan Tolvaptan tedavisi, b\u00f6brek hacmindeki art\u0131\u015f\u0131 yava\u015flat\u0131r ve b\u00f6brek fonksiyon kayb\u0131n\u0131 geciktirebilir<\/strong>.\u201d<\/p>\n<p>T\u00fcrkmen, Tolvaptan tedavisi s\u0131ras\u0131nda hastalar\u0131n d\u00fczenli olarak izlenmesi gerekti\u011fini belirterek, \u201c<strong>S\u0131k idrara \u00e7\u0131kma ve susuzluk hissi g\u00f6r\u00fclebilir; nadiren karaci\u011ferle ilgili yan etkiler ortaya \u00e7\u0131kabilece\u011fi i\u00e7in d\u00fczenli kan testleri b\u00fcy\u00fck \u00f6nem ta\u015f\u0131r<\/strong>\u201d uyar\u0131s\u0131nda bulunuyor.<\/p>\n<p><strong>Gelece\u011fe Umutla Bak\u0131l\u0131yor<\/strong><\/p>\n<p>Prof. Dr. K\u00fcltigin T\u00fcrkmen, t\u0131p d\u00fcnyas\u0131nda ODPKD\u2019ye y\u00f6nelik yakla\u015f\u0131m\u0131n h\u0131zla de\u011fi\u015fti\u011fini vurguluyor: \u201c<strong>Gelecekte her hastan\u0131n genetik yap\u0131s\u0131na uygun ki\u015fiselle\u015ftirilmi\u015f tedavilerle, bu hastal\u0131kla ya\u015fayan bireylerin ya\u015fam kalitesini \u00e7ok daha ileriye ta\u015f\u0131may\u0131 hedefliyoruz<\/strong>.\u201d<\/p>\n<p>Son olarak toplumsal fark\u0131ndal\u0131\u011f\u0131n \u00f6nemine dikkat \u00e7eken T\u00fcrkmen, \u015fu mesajla s\u00f6zlerini tamaml\u0131yor:\u00a0<strong>\u201cErken tan\u0131, do\u011fru tedavi ve d\u00fczenli takip ile ODPKD ile ya\u015famak m\u00fcmk\u00fcnd\u00fcr.\u201d<\/strong><\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p>Kaynak: (BYZHA) Beyaz Haber Ajans\u0131<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Necmettin Erbakan \u00dcniversitesi T\u0131p Fak\u00fcltesi, \u0130\u00e7 Hastal\u0131klar\u0131 Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Nefrolog Prof. Dr. K\u00fcltigin T\u00fcrkmen, Otozomal Dominant Polikistik B\u00f6brek Hastal\u0131\u011f\u0131\u2019n\u0131n (ODPKD) toplumda san\u0131landan daha yayg\u0131n g\u00f6r\u00fclen, ancak fark\u0131ndal\u0131\u011f\u0131 h\u00e2l\u00e2 yeterli olmayan ciddi bir genetik hastal\u0131k oldu\u011funa dikkat \u00e7ekiyor.<\/p>\n","protected":false},"author":1,"featured_media":40195,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[3332,776,1131,577,4221],"class_list":["post-40194","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","tag-bobrek","tag-hastalar","tag-hastaligi","tag-tedavi","tag-turkmen"],"_links":{"self":[{"href":"https:\/\/bihavadis.com\/index.php\/wp-json\/wp\/v2\/posts\/40194","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bihavadis.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bihavadis.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bihavadis.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bihavadis.com\/index.php\/wp-json\/wp\/v2\/comments?post=40194"}],"version-history":[{"count":1,"href":"https:\/\/bihavadis.com\/index.php\/wp-json\/wp\/v2\/posts\/40194\/revisions"}],"predecessor-version":[{"id":40196,"href":"https:\/\/bihavadis.com\/index.php\/wp-json\/wp\/v2\/posts\/40194\/revisions\/40196"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bihavadis.com\/index.php\/wp-json\/wp\/v2\/media\/40195"}],"wp:attachment":[{"href":"https:\/\/bihavadis.com\/index.php\/wp-json\/wp\/v2\/media?parent=40194"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bihavadis.com\/index.php\/wp-json\/wp\/v2\/categories?post=40194"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bihavadis.com\/index.php\/wp-json\/wp\/v2\/tags?post=40194"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}